Asparaginase pharmacokinetics and implications of therapeutic drug monitoring
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چکیده
منابع مشابه
Asparaginase pharmacokinetics and implications of therapeutic drug monitoring
Asparaginase is widely used in chemotherapeutic regimens for the treatment of acute lymphoblastic leukemia (ALL) and has led to a substantial improvement in cure rates, especially in children. Optimal therapeutic effects depend on a complete and sustained depletion of serum asparagine. However, pronounced interpatient variability, differences in pharmacokinetic properties between asparaginases ...
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ژورنال
عنوان ژورنال: Leukemia & Lymphoma
سال: 2015
ISSN: 1042-8194,1029-2403
DOI: 10.3109/10428194.2014.1003056